The car driver, another young passenger and a woman were hospitalized.
Two girls were killed when a sport utility vehicle ran off a road on the near 87th and Quest, which is north of Sorenson Parkway.
The Douglas County Sheriff's Department says the crash occurred about 12:15 a.m. Wednesday near Irvington. Investigators say the SUV didn't stop at a T intersection and flipped over after it ran into a ravine.
Both girls killed were under the age of 5. The driver of the SUV, another young passenger and a woman were hospitalized. 35 year old Christopher Phelps was booked for two counts of motor-vehicle homicide and refusing to take a sobriety test.