The man's five year old son was injured.
Police say 33-year-old Jeremiah Johnson led officers on a chase early Friday morning that exceeded speeds of 110 mph.
The chase began in Clive when an officer tried to pull over Johnson's car and it sped away. The Iowa State Patrol eventually took over and followed the car into Indianola, where it ran into an empty police cruiser at a roadblock on Iowa Highway 92.
Johnson was pronounced dead at the scene. The boy was taken to a hospital. Authorities have not released the child's identify or condition.
Police say Johnson was wanted in Georgia on suspicion of cruelty to a child and reckless driving.